Individualized treatment rule characterization via a value function surrogate

• Published in: Biometrics Vol. 80; no. 1
• Main Authors: Freeman, Nikki L B, Browder, Sydney E, McGinigle, Katharine L, Kosorok, Michael R
• Format: Journal Article
• Language: English
• Published: United States 29.01.2024
• Subjects: Bayes Theorem; Humans; Precision Medicine; precision medicine; surrogate model; Gaussian process; individualized treatment rule; translational science
• ISSN: 0006-341X; 1541-0420
• DOI: 10.1093/biomtc/ujad012

Precision medicine is a promising framework for generating evidence to improve health and health care. Yet, a gap persists between the ever-growing number of statistical precision medicine strategies for evidence generation and implementation in real-world clinical settings, and the strategies for closing this gap will likely be context-dependent. In this paper, we consider the specific context of partial compliance to wound management among patients with peripheral artery disease. Using a Gaussian process surrogate for the value function, we show the feasibility of using Bayesian optimization to learn optimal individualized treatment rules. Further, we expand beyond the common precision medicine task of learning an optimal individualized treatment rule to the characterization of classes of individualized treatment rules and show how those findings can be translated into clinical contexts.