Quantifying irregular pulsation of intracranial aneurysms using 4D-CTA

• Published in: Journal of biomechanics Vol. 174; p. 112269
• Main Authors: Xie, Hujin, Yu, Han, Wu, Hao, Wang, Jiaqiu, Wu, Shanglin, Zhang, Jianjian, Zhao, Huilin, Yuan, Mingyang, Benitez Mendieta, Jessica, Anbananthan, Haveena, Winter, Craig, Zhu, Chengcheng, Li, Zhiyong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2024; Elsevier Limited
• Subjects: 4D-CTA; Algorithms; Aneurysm; Aneurysms; Angiography; Asymptomatic; Blood vessels; Computed tomography; Deformability; Deformation; Eigenvalues; Finite element method; Formability; Heart; Intracranial aneurysm; Irregular pulsation; Medical imaging; Patients; Pulsation; Risk assessment; Rupture; Statistical analysis; Strain; Strain distribution; Visual observation; Irregular pulsation; 4D-CTA; Intracranial aneurysm; Strain
• ISSN: 0021-9290; 1873-2380; 1873-2380
• DOI: 10.1016/j.jbiomech.2024.112269

Recent studies have suggested that irregular pulsation of intracranial aneurysm during the cardiac cycle may be potentially associated with aneurysm rupture risk. However, there is a lack of quantification method for irregular pulsations. This study aims to quantify irregular pulsations by the displacement and strain distribution of the intracranial aneurysm surface during the cardiac cycle using four-dimensional CT angiographic image data. Four-dimensional CT angiography was performed in 8 patients. The image data of a cardiac cycle was divided into approximately 20 phases, and irregular pulsations were detected in four intracranial aneurysms by visual observation, and then the displacement and strain of the intracranial aneurysm was quantified using coherent point drift and finite element method. The displacement and strain were compared between aneurysms with irregular and normal pulsations in two different ways (total and stepwise). The stepwise first principal strain was significantly higher in aneurysms with irregular than normal pulsations (0.20±0.01 vs 0.16±0.02, p=0.033). It was found that the irregular pulsations in intracranial aneurysms usually occur during the consecutive ascending or descending phase of volume changes during the cardiac cycle. In addition, no statistically significant difference was found in the aneurysm volume changes over the cardiac cycle between the two groups. Our method can successfully quantify the displacement and strain changes in the intracranial aneurysm during the cardiac cycle, which may be proven to be a useful tool to quantify intracranial aneurysm deformability and aid in aneurysm rupture risk assessment.