Initiation of spermatogenesis and successful in vitro fertilization in an infertile male with panhypopituitarism; superiority of pulsatile LH-RH over gonadotropins?; a case report

This case report describes an infertile male patient with panhypopituitarism, presumably caused by traumatic breech delivery. Previous hMG/hCG treatment had failed to induce spermatogenesis. Initiation of the production of motile and morphological normal sperm, despite persisting significant oligozo...

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Bibliographic Details
Published inEuropean journal of obstetrics & gynecology and reproductive biology Vol. 40; no. 2; pp. 153 - 157
Main Authors van de Berk, Deon, Wijnberg, Max, van Dop, Peter A.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.07.1991
Elsevier
Subjects
Adult
Biological and medical sciences
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - therapeutic use
Fertilization in Vitro
Follicle Stimulating Hormone - blood
Genital system. Reproduction
Gonadotropin-Releasing Hormone - administration & dosage
Gonadotropin-Releasing Hormone - therapeutic use
Humans
Hypopituitarism - complications
Hypopituitarism - drug therapy
Infertility, Male - drug therapy
Infertility, Male - etiology
IVF
LH-RH
Luteinizing Hormone - blood
Male
Male hypogonadism
Medical sciences
Menotropins - administration & dosage
Menotropins - therapeutic use
Oligospermia - complications
Oligospermia - drug therapy
Pharmacology. Drug treatments
Sperm motility
Spermatogenesis
Testosterone - blood
IVF
Sperm motility
Male hypogonadism
LH-RH
Endocrinopathy
Human
Induction
Spermatogenesis
Gonadotropin RH
Case study
In vitro fertilization embryo transfer
Chemotherapy
Treatment
Pulsatile
Pituitary diseases
Panhypopituitarism
Male sterility
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Summary:This case report describes an infertile male patient with panhypopituitarism, presumably caused by traumatic breech delivery. Previous hMG/hCG treatment had failed to induce spermatogenesis. Initiation of the production of motile and morphological normal sperm, despite persisting significant oligozoospermia was established with s.c. pulsatile LH-RH treatment. Spermatogenesis could be maintained with i.m. hCG injections bi-weekly. Later, fruitful in vitro fertilization (IVF) resulted in the birth of a healthy daughter.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0301-2115
1872-7654
DOI:10.1016/0028-2243(91)90108-W