The relationship between lower urinary tract function and 123ioflupane scintigraphy in drug-naïve Parkinson's disease

• Published in: Autonomic neuroscience Vol. 233; p. 102813
• Main Authors: Tateno, Fuyuki, Sakakibara, Ryuji, Ogata, Tsuyoshi, Aiba, Yousuke, Takahashi, Osamu, Sugiyama, Megumi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2021
• Subjects: Autonomic failure; Lower urinary tract dysfunction; Parkinson's disease; SPECT imaging of the dopamine transporter with 123I -FP-CIT; Lower urinary tract dysfunction; Parkinson's disease; SPECT imaging of the dopamine transporter with 123I -FP-CIT; Autonomic failure
• ISSN: 1566-0702; 1872-7484
• DOI: 10.1016/j.autneu.2021.102813

Parkinson's disease (PD) is the most common degenerative cause of movement disorder, and autonomic dysfunction has been recognized in this disorder. PD patients' lower urinary tract (LUT) function is not established. We investigated LUT function in PD by single-photon emission computerized tomography (SPECT) imaging of the dopamine transporter with 123I-ioflupane and clinical-urodynamic observations. We retrospectively analyzed the cases of 30 patients diagnosed with PD based on published criteria who completed a systematized lower urinary tract symptoms (LUTS) questionnaire and a urodynamics examination irrespective of the presence of LUTS. None of the patients were taking anti-parkinsonian medication during the study. The questionnaire revealed that all 30 patients had LUTS: night-time urinary frequency (in 70%), urinary incontinence (40%), and daytime urinary frequency (80%). A urodynamic study revealed a mean volume at the first sensation at 92.3 ml, bladder capacity at 200.9 ml, and detrusor overactivity in 50%. Sphincter electromyography revealed neurogenic change in 13.6% of those for whom the test was performed. The average SBR showed a significant correlation with bladder capacity (Spearman's correlation coefficient p = 0.0076) and Hoehn Yahr motor stage (Spearman's correlation coefficient p = 0.012). Our findings demonstrate that the striatum is relevant to the higher control of storage in micturition function in PD.