Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study

Breath composition is altered in liver diseases. We tested if ion-molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis in liver diseases. We analysed 114 molecules in the breath of 126 individuals (healthy controls,...

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Published inBiomarkers Vol. 15; no. 4; pp. 297 - 306
Main Authors Millonig, Gunda, Praun, Siegfried, Netzer, Michael, Baumgartner, Christian, Dornauer, Albert, Mueller, Sebastian, Villinger, Johannes, Vogel, Wolfgang
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.06.2010
Taylor & Francis
Subjects
Acetaldehyde - analysis
Adult
Aged
Biomarkers
Breath Tests
Butadienes - analysis
Diagnostics
Ethanol - analysis
exhalation
fatty liver
Fatty Liver - diagnosis
Fatty Liver, Alcoholic - diagnosis
Female
foetor hepaticus
Hemiterpenes - analysis
Humans
Liver Cirrhosis - diagnosis
Liver Diseases - classification
Liver Diseases - diagnosis
Male
Mass Spectrometry
Middle Aged
Pentanes - analysis
Pilot Projects
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Summary:Breath composition is altered in liver diseases. We tested if ion-molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis in liver diseases. We analysed 114 molecules in the breath of 126 individuals (healthy controls, and patients with non-alcoholic and alcoholic fatty liver disease and liver cirrhosis) by IMR-MS. Characteristic exhalation patterns were identified for each group. Combining two to seven molecules in the new stacked feature ranking model reached a diagnostic accuracy (area under the curve) for individual liver diseases between 0.88 and 0.97. IMR-MS followed by sophisticated statistical analysis is a promising tool for liver diagnostics by breath analysis.
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ISSN:1354-750X
1366-5804
DOI:10.3109/13547501003624512