The effects of coadministration palmitic acid and oleic acid (omega 9) on spatial learning and motor activity in adult male rat

• Published in: Pakistan journal of biological sciences Vol. 10; no. 20; pp. 3650 - 3655
• Main Authors: Moazedi, A A, Hossienzadeh, Z, Chinpardaz, R
• Format: Journal Article
• Language: English
• Published: Pakistan 15.10.2007
• Subjects: Animals; Diet; Dietary Fats; Humans; Male; Maze Learning - drug effects; Motor Activity - drug effects; Oleic Acid - pharmacology; Palmitic Acid - pharmacology; Random Allocation; Rats; Rats, Wistar; Rotarod Performance Test
• ISSN: 1028-8880
• DOI: 10.3923/pjbs.2007.3650.3655

In this study, the effects of oleic acid (10%) and palmitic acid (10%) on spatial learning and motor activity have been investigated. So, adult male Wister rats divided into four groups (n=10). Control group was fed with ordinary diet. other groups were fed with a diet containing oleic acid (10%) for 4 weeks or palmitic acid (10%) for 1 week. Also, coadministration group was fed with a diet containing oleic acid (10%) for 4 weeks plus palmitic acid (10%) for 1 week. In next step, rats were trained for spatial learning task by using T-maze at subsequently 9 days. Moreover, rats were tested for motor activity task by using Rota rod based on standard method. The results showed that the spatial learning and motor activity were significantly (p < 0.01, p < 0.001) increased in rats fed with oleic acid (10%) for 4 weeks. Also Spatial learning and motor activity were significantly (p < 0.001, p < 0.001) increased due to the diet containing palmitic acid 10% for 1 week. Also the Spatial learning and motor activity were significantly (p < 0.01, p < 0.001) increased in coadministration group diet containing oleic acid (10%) for 4 weeks and palmitic acid (10%) for 1 week but statistical test between three diet groups were not significant. A consensus has emerged from recent research that it is important the balance of the different type of fats. Because the type of fatty acids in the diet and ratio of these fatty acids determines the type of fatty acids that is available to the composition of cell membranes spatially in nerves system.