Integrated Zeolite Based Carbon Paste Electrode for Sensitive Voltammetric Assay of Ticagrelor

• Published in: Arabian journal for science and engineering (2011) Vol. 48; no. 1; pp. 539 - 549
• Main Authors: Al-Nami, Samar Y., Hameed, Ahmed, Azher, Omer A., Alamrani, Nasser A., Aljuhani, Enas, Abumelha, Hana M., El-Metwaly, Nashwa M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2023; Springer Nature B.V
• Subjects: Carbon; Electrochemical analysis; Electrodes; Engineering; Humanities and Social Sciences; Molecular orbitals; multidisciplinary; Oxidation; Reaction mechanisms; Research Article-Chemistry; Science; Sensors; Spectrophotometry; Voltammetry; Zeolites; Zeolite nanostructure; Voltammetry; Ticagrelor sensor; Biological samples; Oxidation mechanism
• ISSN: 2193-567X; 1319-8025; 2191-4281
• DOI: 10.1007/s13369-022-07306-2

Herein, the construction and the electroanalytical applications of novel ticagrelor (TIC) voltammetric sensors were described. Integration of the working carbon paste electrodes with zeolite nanostructures showed a proper electrocatalytic activity toward oxidation of the TIC molecule. At the optimum measuring conditions, TIC showed an irreversible oxidation peak at 0.954 V with an assumed diffusion–reaction mechanism. Based on the electrochemical behavior at different pH and the scan rate values, the electrode reaction takes place through oxidation of the N Enamine of the ticagrelor moiety with the participation of one electron and one proton in agreement with the molecular orbital calculations. Calibration curves showed improved linearity ( r  = 0.9998) within the TIC concentration ranging from 8.8 to 1665 ng mL −1 with LOD and LOQ values of 2.5 and 7.5 ng mL −1 , respectively. The introduced TIC voltammetric sensor exhibited improved performance with high measurement reproducibility and prolonged operational lifetime. The cited ZY/CPEs sensors were capable of simultaneous voltammetric determination of TIC in the existence of its degradation outcomes and expected interferents. The proposed voltammetric approach was suggested for the sensitive determination of ticagrelor in biological fluids and pharmaceutical samples with good recovery values in agreement with the spectrophotometric measurements.