DNA hypomethylation and upregulated LINC00518 acts as a promoter and biomarker in head and neck squamous cell carcinoma

acts as an oncogene in several cancers, but its function in head and neck squamous cell carcinoma (HNSCC) remains unclear. The expression and methylation status of were analyzed by reviewing public databases. The ceRNA network and the relationship with tumor immunity of were analyzed using online to...

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Published inEpigenomics Vol. 15; no. 5; pp. 293 - 306
Main Authors Wang, Xueqin, Shen, Jinquan, Wang, Laifa, Deng, Ling, Bo, Hao, Luo, Yanwei, Cui, Yanhui
Format Journal Article
LanguageEnglish
Published England 01.03.2023
Subjects
Biomarkers, Tumor - genetics
Cell Line, Tumor
DNA
DNA Methylation
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms - genetics
Humans
Prognosis
RNA, Long Noncoding
Squamous Cell Carcinoma of Head and Neck - genetics
lncRNAs
HMGA2
tumor immunity
gene-based therapy
head and neck squamous cell carcinoma (HNSCC)
hypomethylation
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Summary:acts as an oncogene in several cancers, but its function in head and neck squamous cell carcinoma (HNSCC) remains unclear. The expression and methylation status of were analyzed by reviewing public databases. The ceRNA network and the relationship with tumor immunity of were analyzed using online tools and studies. Upregulated was associated with poor clinicopathological characteristics of HNSCC. Silencing significantly inhibited the migration of HNSCC cells. might positively regulate via the ceRNA mechanism. Additionally, was negatively correlated with various immune cells and immunotherapy markers. Moreover, the upregulation of in HNSCC may be due to DNA hypomethylation. may be a potential biomarker and therapeutic target for HNSCC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2023-0053