Ecofriendly Synthesis of Ribociclib Intermediate Using Regioselective Hydrodechlorination and DMAP Catalyzed Ester Hydrolysis

This work reports the execution of Ecofriendly methods for the synthesis of Ribociclib precursor. Hazardous solvent free methodologies were optimized by using non hazardous and renewable solvents such as EtOH and DMSO. Highly abundant and biologically relavent Zinc metal was employed for Hydrodechlo...

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Bibliographic Details
Published inTopics in catalysis Vol. 65; no. 19-20; pp. 1669 - 1674
Main Authors Udayasri, Allu, Chandrasekhar, Manchikanti M., Brahmeswararao, M. V. N., Varanasi, Ganesh, Praveen, P. Lakshmi, Ramakrishna, D. S.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2022
Springer Nature B.V
Subjects
Catalysis
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Hydrodechlorination
Hydrolysis
Industrial Chemistry/Chemical Engineering
Original Paper
Pharmacy
Physical Chemistry
Solvents
Hydrodechlorination
DMAP catalyst
Green synthesis
Halogen solvent free synthesis
Ester hydrolysis
Economically friendly synthesis
Ribociclib intermediate
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Summary:This work reports the execution of Ecofriendly methods for the synthesis of Ribociclib precursor. Hazardous solvent free methodologies were optimized by using non hazardous and renewable solvents such as EtOH and DMSO. Highly abundant and biologically relavent Zinc metal was employed for Hydrodechlorination reaction along with Recommended solvent EtOH. DMAP catalyzed Ester hydrolysis reaction was performed using recommended solvent EtOH instead of MeOH. Amidation reaction was optimized using DMSO solvent instead of hazardous solvents such as DMF or NMP. Graphical Abstract
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ISSN:1022-5528
1572-9028
DOI:10.1007/s11244-022-01602-9