THE FIRST SYNTHESIS OF A MODEL BICYCLIC D-O-E-F-O-G RING OF TEICOPLANIN VIA SEQUENTIAL INTRAMOLECULAR SNAR REACTIONS

A model bicyclic D-O-E-F-O-G ring (2) of teicoplanin (1) has been efficiently synthesized via sequential intramolecular SNAr reactions.

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Bibliographic Details
Published inTetrahedron letters Vol. 36; no. 48; pp. 8787 - 8790
Main Authors BEUGELMANS, R, NEUVILLE, L, BOISCHOUSSY, M, ZHU, JP
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 27.11.1995
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CARBOXYLATE-BINDING POCKET
GLYCOPEPTIDE ANTIBIOTICS
TRANSFORMATION
ASYMMETRIC-SYNTHESIS
ALANYL-D-ALANINE
RISTOCETIN
VANCOMYCIN RESISTANCE
BIOMIMETIC APPROACH
PEPTIDE-SYNTHESIS
MACROCYCLIZATION
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Summary:A model bicyclic D-O-E-F-O-G ring (2) of teicoplanin (1) has been efficiently synthesized via sequential intramolecular SNAr reactions.
ISSN:0040-4039
DOI:10.1016/0040-4039(95)01876-J