Long-term increase in peritoneal membrane transport rates following incidental intraperitoneal sodium hypochlorite infusion

A patient on continuous ambulatory peritoneal dialysis using an "O" set connection system with sodium hypochlorite as a disinfectant incidentally infused the disinfectant intraperitoneally on two occasions. The product of peritoneal membrane permeability and peritoneal membrane surface are...

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Bibliographic Details
Published inInternational journal of artificial organs Vol. 12; no. 11; p. 711
Main Authors Dedhia, N M, Schmidt, L M, Twardowski, Z J, Khanna, R, Nolph, K D
Format Journal Article
LanguageEnglish
Published United States 01.11.1989
Subjects
Dialysis Solutions
Humans
Infusions, Parenteral
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory
Peritoneum - physiopathology
Permeability - drug effects
Sodium Hypochlorite - administration & dosage
Sodium Hypochlorite - poisoning
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Summary:A patient on continuous ambulatory peritoneal dialysis using an "O" set connection system with sodium hypochlorite as a disinfectant incidentally infused the disinfectant intraperitoneally on two occasions. The product of peritoneal membrane permeability and peritoneal membrane surface area increased after both infusions as judged by peritoneal equilibration test results and/or serum chemistries. Elevated peritoneal solute transport rates and reduced ultrafiltration gradually subsided but did not return to preinfusion values. This observation suggests that intraperitoneal sodium hypochlorite infusion may cause significant long-term alteration in peritoneal membrane transport characteristics.
ISSN:0391-3988
DOI:10.1177/039139888901201109