Visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids
A visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids is described. This reaction relies on the use of readily accessible and stable α-ketoacids to achieve the hydroacylation of α-branched 2-vinylpyridines, providing a mild and efficient method for the s...
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Published in | Tetrahedron Vol. 160; pp. 134042 - 134048 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
29.06.2024
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids is described. This reaction relies on the use of readily accessible and stable α-ketoacids to achieve the hydroacylation of α-branched 2-vinylpyridines, providing a mild and efficient method for the synthesis of pyridine derivatives. The reactions of various α-branched 2-vinylpyridines with α-ketoacids show the generality of this method.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2024.134042 |