Visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids

A visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids is described. This reaction relies on the use of readily accessible and stable α-ketoacids to achieve the hydroacylation of α-branched 2-vinylpyridines, providing a mild and efficient method for the s...

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Bibliographic Details
Published inTetrahedron Vol. 160; pp. 134042 - 134048
Main Authors Zhao, Jia-Jia, Cao, Qing-Ling, Zuo, Kang, Yue, Xiaoyi, Cui, Xinyan, Chen, Li-Zhuang
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.06.2024
Elsevier
Subjects
Chemistry
Chemistry, Organic
Giese reaction
Photoredox
Physical Sciences
Pyridine
Science & Technology
α-ketoacids
Giese reaction
α-ketoacids
Pyridine
Photoredox
CATALYSIS
COMPLEX
alpha-ketoacids
CYANATION
DISCOVERY
ALCOHOLS
AMINO RADICALS
BETA-ALKYLATION
GENERATION
CONJUGATE ADDITIONS
CARBOXYLIC-ACIDS
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Summary:A visible-light-mediated photoredox Giese reaction with α-branched 2-vinylpyridines and α-ketoacids is described. This reaction relies on the use of readily accessible and stable α-ketoacids to achieve the hydroacylation of α-branched 2-vinylpyridines, providing a mild and efficient method for the synthesis of pyridine derivatives. The reactions of various α-branched 2-vinylpyridines with α-ketoacids show the generality of this method. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2024.134042