Metastatic intracranial carcinoid with immunohistochemical observation. Case report

A case of metastatic carcinoid tumor in the right occipital lobe originating from a primary tumor in the right colon is reported in a 68-year-old man. The tumor had a high bromodeoxyuridine labeling index. Although immunohistochemical studies of the tumor specimen showed positive reactivity for sero...

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Published inJournal of neurosurgery Vol. 73; no. 1; p. 130
Main Authors Ozawa, T, Terabayashi, T, Takahashi, H, Takeda, N, Ito, Y, Saito, A, Sugiyama, Y, Ikuta, F
Format Journal Article
LanguageEnglish
Published United States 01.07.1990
Subjects
Aged
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain Neoplasms - secondary
Bromodeoxyuridine - metabolism
Carcinoid Tumor - metabolism
Carcinoid Tumor - pathology
Carcinoid Tumor - secondary
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Humans
Immunohistochemistry
Male
Occipital Lobe - pathology
Serotonin - metabolism
Somatostatin - metabolism
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Summary:A case of metastatic carcinoid tumor in the right occipital lobe originating from a primary tumor in the right colon is reported in a 68-year-old man. The tumor had a high bromodeoxyuridine labeling index. Although immunohistochemical studies of the tumor specimen showed positive reactivity for serotonin and somatostatin, blood levels of serotonin and urinary 5-hydroxyindoleacetic acid content were normal. This suggests that coexistence of somatostatin with serotonin in the tumor tissue might lead to inhibition of serotonin release by "autocrine regulation." The neurological complications of carcinoid tumors, including intracranial metastasis, are discussed briefly.
ISSN:0022-3085
DOI:10.3171/jns.1990.73.1.0130