A method for the synthesis of spiro-1,3,4-thiadiazolines

A method for the synthesis of spiro-1,3,4-thiadiazolines by the reaction of cyclic ketones with oxamic acid thiohydrazides was developed. A number of new nonsteroidal spiro-1,3,4-thiadiazolines was obtained in high yields.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 60; no. 3-4; pp. 183 - 189
Main Authors Komkov, Alexander V., Menchikov, Leonid G., Dmitrenok, Andrey S., Kolotyrkina, Natalya G., Zavarzin, Igor V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2024
Springer Nature
Springer Nature B.V
Subjects
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Ketones
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
cyclic ketones
spiro-1,3,4-thiadiazolines
oxamic acid thiohydrazides
MONOTHIOOXAMIDES
THIOHYDRAZIDES
ACYLATION
BEHAVIOR
TERPENONES
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Summary:A method for the synthesis of spiro-1,3,4-thiadiazolines by the reaction of cyclic ketones with oxamic acid thiohydrazides was developed. A number of new nonsteroidal spiro-1,3,4-thiadiazolines was obtained in high yields.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-024-03316-0