New insights into molecular structure and function of ecto-nucleotidases in the nervous system

Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure...

Full description

Saved in:
Bibliographic Details
Published inNeurochemistry international Vol. 32; no. 5-6; pp. 421 - 425
Main Authors Zimmermann, H, Braun, N, Kegel, B, Heine, P
Format Journal Article
LanguageEnglish
Published 01.05.1998
Online AccessGet full text

Cover

More Information
Summary:Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure of an ecto-ATPase and an ecto-ATP diphosphohydrolase, two closely related ecto-enzymes. Molecular structure, tissue distribution and functional properties of the ecto-nucleotidases are discussed with particular emphasis on the nervous system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0197-0186
DOI:10.1016/S0197-0186(97)00126-5