Utility of methicillin-resistant Staphylococcus aureus nasal PCR testing in pediatric patients with suspected respiratory infections

Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children wi...

Full description

Saved in:
Bibliographic Details
Published inJournal of the Pediatric Infectious Diseases Society Vol. 13; no. 4; pp. 242 - 245
Main Authors Baker, Brooke, Hung, Frances, Smith, Michael J, Erkanli, Alaattin, Greenhill, Katherine, Hayes, Jillian, Parish, Alice, Zhou, Grace, Moorthy, Ganga S, Deri, Connor R
Format Journal Article
LanguageEnglish
Published England 24.04.2024
Subjects
de-escalation
antimicrobial stewardship
children
nasal swab
MRSA
Online AccessGet full text

Cover

Abstract Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children with suspected respiratory infections.
AbstractList Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children with suspected respiratory infections.
Abstract Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however, pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children with suspected respiratory infections.
Author Baker, Brooke
Greenhill, Katherine
Hung, Frances
Moorthy, Ganga S
Deri, Connor R
Smith, Michael J
Hayes, Jillian
Erkanli, Alaattin
Parish, Alice
Zhou, Grace
Author_xml – sequence: 1
  givenname: Brooke
  surname: Baker
  fullname: Baker, Brooke
  organization: Department of Pharmacy, Duke University Medical Center, Durham, North Carolina, USA
– sequence: 2
  givenname: Frances
  surname: Hung
  fullname: Hung, Frances
  organization: Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA
– sequence: 3
  givenname: Michael J
  surname: Smith
  fullname: Smith, Michael J
  organization: Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, North Carolina, USA
– sequence: 4
  givenname: Alaattin
  surname: Erkanli
  fullname: Erkanli, Alaattin
  organization: Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA
– sequence: 5
  givenname: Katherine
  surname: Greenhill
  fullname: Greenhill, Katherine
  organization: Department of Pharmacy, Duke University Medical Center, Durham, North Carolina, USA
– sequence: 6
  givenname: Jillian
  orcidid: 0000-0002-0132-5136
  surname: Hayes
  fullname: Hayes, Jillian
  organization: Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, North Carolina, USA
– sequence: 7
  givenname: Alice
  surname: Parish
  fullname: Parish, Alice
  organization: Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA
– sequence: 8
  givenname: Grace
  surname: Zhou
  fullname: Zhou, Grace
  organization: Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA
– sequence: 9
  givenname: Ganga S
  orcidid: 0000-0003-3191-1117
  surname: Moorthy
  fullname: Moorthy, Ganga S
  organization: Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, North Carolina, USA
– sequence: 10
  givenname: Connor R
  orcidid: 0000-0002-9626-1197
  surname: Deri
  fullname: Deri, Connor R
  organization: Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, North Carolina, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38466576$$D View this record in MEDLINE/PubMed
BookMark eNpNkM1r3DAQxUVJaT6aY69Fx17cSJYs2cey9AsCDWlyNrPyuDvBK6mSTNh7__AqzbZ0DvOG4TeP4Z2zEx88MvZGivdSDOrqIdKUryIBila9YGet0H1jW2FP_ptP2WXOD6KW6WTX61fsVPXamM6aM_brvtBC5cDDzPdYduRoWcg3CTPlAr7w7wXi7rAEF5xbM4c1YRUPGRZ-s7nlBXMh_4OT5xEngpLI8QiF0JfMH6nseF5zRFdw4tU2UoIS0qEezHVJwefX7OUMS8bLo16w-08f7zZfmutvn79uPlw3rtVDafpOtgPaSTur1TzbGY016MDIYTCt6rQ1RrbYb9F1qEBMMCjUsO2FBI1uqy7Yu2ffmMLPtf497ik7XBbwGNY8tkNnpKndVrR5Rl0KOSecx5hoD-kwSjE-ZT_-yX48Zl_5t0frdbvH6R_9N2n1G5QJh4c
Cites_doi 10.3390/antibiotics10121434
10.1093/ajhp/zxab296
10.1093/jpids/piad011
10.3390/pharmacy8020101
10.1002/lary.26535
10.1128/AAC.02432-16
10.1093/cid/ciy024
10.1086/345476
10.1128/AAC.01805-13
10.1093/ajhp/zxab109
ContentType Journal Article
Copyright The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Copyright_xml – notice: The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1093/jpids/piae023
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList PubMed
CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2048-7207
EndPage 245
ExternalDocumentID 10_1093_jpids_piae023
38466576
Genre Journal Article
GroupedDBID .2P
.I3
0R~
4.4
48X
53G
5WD
AABZA
AACZT
AAJKP
AAKDD
AAMVS
AAOGV
AAPQZ
AAPXW
AARHZ
AAUAY
AAVAP
ABDBF
ABEJV
ABEUO
ABIXL
ABJNI
ABKDP
ABNHQ
ABNKS
ABPTD
ABQLI
ABQNK
ABWST
ABXVV
ABZBJ
ACGFS
ACUFI
ACUTO
ACYHN
ADBBV
ADEYI
ADGZP
ADHKW
ADHZD
ADIPN
ADJQC
ADOCK
ADQBN
ADRIX
ADRTK
ADVEK
ADYVW
ADZXQ
AEGPL
AEJOX
AEKSI
AEMDU
AENZO
AEPUE
AETBJ
AEWNT
AFFZL
AFIYH
AFOFC
AFXAL
AFXEN
AGINJ
AGQXC
AGSYK
AGUTN
AHXPO
AJEEA
ALMA_UNASSIGNED_HOLDINGS
ALUQC
APIBT
ATGXG
AVWKF
AXUDD
BAYMD
BCRHZ
BEYMZ
BHONS
BTRTY
BVRKM
C45
CDBKE
DAKXR
DILTD
D~K
EBS
EE~
ENERS
F9B
FECEO
FLUFQ
FOEOM
FOTVD
FQBLK
GAUVT
GJXCC
H5~
HAR
HW0
HZ~
J21
KOP
KQ8
KSI
KSN
MHKGH
NGC
NOMLY
NOYVH
NPM
O9-
OAUYM
OAWHX
OCZFY
ODMLO
OJQWA
OJZSN
OPAEJ
OVD
OWPYF
PAFKI
PEELM
Q1.
Q5Y
ROX
RUSNO
RW1
RXO
TEORI
TJX
YAYTL
YKOAZ
YXANX
AASNB
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c249t-85129e7d4c743ff7fe676eca61996235476612e8bec5e3a0da93e4ab801a4ecb3
ISSN 2048-7207
IngestDate Sat Oct 26 05:33:37 EDT 2024
Fri Aug 23 03:21:23 EDT 2024
Sat Nov 02 12:28:02 EDT 2024
IsPeerReviewed false
IsScholarly true
Issue 4
Keywords de-escalation
antimicrobial stewardship
children
nasal swab
MRSA
Language English
License The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c249t-85129e7d4c743ff7fe676eca61996235476612e8bec5e3a0da93e4ab801a4ecb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-0132-5136
0000-0002-9626-1197
0000-0003-3191-1117
PMID 38466576
PQID 2956162957
PQPubID 23479
PageCount 4
ParticipantIDs proquest_miscellaneous_2956162957
crossref_primary_10_1093_jpids_piae023
pubmed_primary_38466576
PublicationCentury 2000
PublicationDate 2024-04-24
PublicationDateYYYYMMDD 2024-04-24
PublicationDate_xml – month: 04
  year: 2024
  text: 2024-04-24
  day: 24
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Journal of the Pediatric Infectious Diseases Society
PublicationTitleAlternate J Pediatric Infect Dis Soc
PublicationYear 2024
References Huffman (2024042405315676300_CIT0007) 2020; 8
Diep (2024042405315676300_CIT0008) 2021; 78
Cosgrove (2024042405315676300_CIT0001) 2003; 36
Dangerfield (2024042405315676300_CIT0003) 2014; 58
Diseroad (2024042405315676300_CIT0011) 2023; 12
Bradford (2024042405315676300_CIT0009) 2017; 127
Turner (2024042405315676300_CIT0006) 2021; 78
Sands (2024042405315676300_CIT0010) 2021; 10
Baby (2024042405315676300_CIT0004) 2017; 61
Inagaki (2024042405315676300_CIT0002) 2019; 69
Parente (2024042405315676300_CIT0005) 2018; 67
References_xml – volume: 10
  start-page: 1434
  year: 2021
  ident: 2024042405315676300_CIT0010
  article-title: Utility of methicillin-resistant Staphylococcus aureus nares screening in hospitalized children with acute infectious disease syndromes
  publication-title: Antibiotics (Basel)
  doi: 10.3390/antibiotics10121434
  contributor:
    fullname: Sands
– volume: 78
  start-page: 2236
  year: 2021
  ident: 2024042405315676300_CIT0008
  article-title: Effect of rapid methicillin-resistant Staphylococcus aureus nasal polymerase chain reaction screening on vancomycin use in the intensive care unit
  publication-title: Am J Health Syst Pharm
  doi: 10.1093/ajhp/zxab296
  contributor:
    fullname: Diep
– volume: 12
  start-page: 184
  year: 2023
  ident: 2024042405315676300_CIT0011
  article-title: The clinical utility of MRSA nasal surveillance swabs in ruling-out MRSA infections in children
  publication-title: J Pediatric Infect Dis Soc
  doi: 10.1093/jpids/piad011
  contributor:
    fullname: Diseroad
– volume: 8
  start-page: 101
  year: 2020
  ident: 2024042405315676300_CIT0007
  article-title: Impact of nasal swabs on empiric treatment of respiratory tract infections (INSERT-RTI)
  publication-title: Pharmacy (Basel)
  doi: 10.3390/pharmacy8020101
  contributor:
    fullname: Huffman
– volume: 127
  start-page: 2407
  year: 2017
  ident: 2024042405315676300_CIT0009
  article-title: Utility of nasal swab and age in detecting methicillin-resistant Staphylococcus aureus in pediatric head and neck abscesses
  publication-title: Laryngoscope
  doi: 10.1002/lary.26535
  contributor:
    fullname: Bradford
– volume: 61
  start-page: e02432
  year: 2017
  ident: 2024042405315676300_CIT0004
  article-title: Nasal methicillin-resistant Staphylococcus aureus (MRSA) PCR testing reduces the duration of MRSA-targeted therapy in patients with suspected MRSA pneumonia
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.02432-16
  contributor:
    fullname: Baby
– volume: 67
  start-page: 1
  year: 2018
  ident: 2024042405315676300_CIT0005
  article-title: The clinical utility of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening to rule out MRSA pneumonia: a diagnostic meta-analysis with antimicrobial stewardship implications
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciy024
  contributor:
    fullname: Parente
– volume: 36
  start-page: 53
  year: 2003
  ident: 2024042405315676300_CIT0001
  article-title: Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
  publication-title: Clin Infect Dis
  doi: 10.1086/345476
  contributor:
    fullname: Cosgrove
– volume: 58
  start-page: 859
  year: 2014
  ident: 2024042405315676300_CIT0003
  article-title: Predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swab PCR assay for MRSA pneumonia
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.01805-13
  contributor:
    fullname: Dangerfield
– volume: 78
  start-page: S57
  year: 2021
  ident: 2024042405315676300_CIT0006
  article-title: Evaluation of the timing of MRSA PCR nasal screening: how long can a negative assay be used to rule out MRSA-positive respiratory cultures
  publication-title: Am J Health Syst Pharm
  doi: 10.1093/ajhp/zxab109
  contributor:
    fullname: Turner
– volume: 69
  start-page: 2112
  year: 2019
  ident: 2024042405315676300_CIT0002
  article-title: Methicillin-susceptible and methicillin-resistant Staphylococcus aureus bacteremia: nationwide estimates of 30-day readmission, in-hospital mortality, length of stay, and cost in the United States
  publication-title: Clin Infect Dis
  contributor:
    fullname: Inagaki
SSID ssj0000651584
Score 2.3307424
Snippet Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling...
Abstract Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
StartPage 242
Title Utility of methicillin-resistant Staphylococcus aureus nasal PCR testing in pediatric patients with suspected respiratory infections
URI https://www.ncbi.nlm.nih.gov/pubmed/38466576
https://search.proquest.com/docview/2956162957
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIiEuqDwbHtUiIS6VW2e9fvRY2qICagUlEb1Za3tWMlROFdsXzv2B_CRmdtd2QoNUuDiRlYwVz5fZz7PfzDD2ZqKlUBBJTwk_9uS-jrwkBPDUBPyskOFEK6O2OItOZvLjRXgxGv1aUi21Tbab_1xbV_I_XsVz6Feqkv0Hz_ZG8QS-R__iET2Mx1v5eNaUl05ScQokXKfkSeWdQ02ssGqISuJtxPVqnudtvaPaBeDLmarRMZ8Pz3em1GPDFrX0Mzuoa39p6t6-UY72a2uKMYHKGIdd-Q9Ow-VyfTfZLfHZwWT3cbz4kd0Rqju96JBKdfqOdwvqAjrAzQYjMwBk0Dv2CSEn-x92t44XP1Rla74PLpVqutbiLrMhjCDGFlTbAEg9hb1Y2Km4u7DmXBfBgyWkyuVwbDt3uZVd2MaVNxYN21Dr-1VZ1DTxuFTg2xro1fbcfyybvZjRbuMHqTGQuq_fYXcFhj6KuZ--JH3Wz6fJ82YMdv9DXONXtLBnLOw5C6tE6S9PP4YFTTfZA-dgfmCx-JCNoHrE7p06gcZjdu0gyeear4UkX4Ukt5DkBpIcIckdJHlZ8R4_vIMkJ0jyHpJ8CZJ8gOQTNnt_PD088dygDy_Hp_8GowOyTogLmSOf1TrWEMUR5CoiibwIQhkjixSQYLwJIVB-ofYDkCpDdqUk5FnwlG1U8wq2GC8SWUyKPBRRnlB3u0xnceGDFBnyMF2EY_a2u6vple3nkq514Ji97u55ihGXttFUBfg_SQXVgkd4jMfsmXVGbypAOh_hI_zz217mBbs_QP8l22gWLbxCmttk2wY5vwHlwrQ7
link.rule.ids 315,783,787,27936,27937
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Utility+of+Methicillin-Resistant+Staphylococcus+aureus+Nasal+PCR+Testing+in+Pediatric+Patients+With+Suspected+Respiratory+Infections&rft.jtitle=Journal+of+the+Pediatric+Infectious+Diseases+Society&rft.au=Baker%2C+Brooke&rft.au=Hung%2C+Frances&rft.au=Smith%2C+Michael+J&rft.au=Erkanli%2C+Alaattin&rft.date=2024-04-24&rft.issn=2048-7207&rft.eissn=2048-7207&rft.volume=13&rft.issue=4&rft.spage=242&rft.epage=245&rft_id=info:doi/10.1093%2Fjpids%2Fpiae023&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_jpids_piae023
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2048-7207&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2048-7207&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2048-7207&client=summon