Physico-chemical behavior and microstructural manipulation of nanocomposites containing hydroxyapatite, alumina, and graphene oxide

• Published in: Applied physics. A, Materials science & processing Vol. 128; no. 4
• Main Authors: Almotiri, Reim A., Alkhamisi, Manal M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer Nature B.V
• Subjects: Aluminum oxide; Applied physics; Biomedical materials; Characterization and Evaluation of Materials; Condensed Matter Physics; E coli; Fourier transforms; Graphene; Hydroxyapatite; Infrared analysis; Infrared spectroscopy; Machines; Manufacturing; Materials science; Microhardness; Nanocomposites; Nanorods; Nanotechnology; Optical and Electronic Materials; Photoelectrons; Physics; Physics and Astronomy; Processes; Roughness; Spectrum analysis; Surfaces and Interfaces; Thin Films; Toxicity; X ray analysis; Nanocomposite antibacterial; Hydroxyapatite; Graphene oxide; Alumina
• ISSN: 0947-8396; 1432-0630
• DOI: 10.1007/s00339-022-05479-z

Ternary nanocomposites based on hydroxyapatite (HAP) and alumina (Al 2 O 3 ) were embedded through graphene oxide (GO) nanosheets to be investigated for medical applications. The composition of the preparations has been confirmed by X-ray photoelectron spectroscopy, energy-dispersive X-ray analysis, and Fourier-Transform infrared spectroscopy. Scanning and transmission electron microscopy have shown the typical morphologies of the components of the nanocomposites with hydroxyapatite nanorods reaching an average diameter of 22.26 ± 2 nm and an average length of 69.56 ± 19.25 nm in the ternary nanocomposites. The ternary nanocomposite has a microhardness of 5.8 ± 0.1 GPa and a higher average roughness of 6.5 nm compared to pure HAP preparation with an average roughness of 2.7 nm. All preparations have shown an acceptable cytotoxicity profile with a percent osteoblasts cell viability of 98.6 ± 1.3% after culturing with the ternary nanocomposite. The TNC has also shown the highest antibacterial activity compared to preparations of each of its constituents and their nanocomposites, with a zone of inhibition’s diameter of 14.1 ± 0.8 mm and 13.6 ± 0.6 mm against Staphylococcus aureus and Escherichia coli , respectively, compared to no zone of inhibition for the pure hydroxyapatite preparation.