Anchoring of silver nanoparticles by a zinc-porphyrin covalent organic framework for synergistic photodynamic sterilization

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 492; p. 152293
• Main Authors: Fu, Quanbin, Zhang, Tingting, An, Mouzhen, Sun, Xin, Li, Yijing, Zhang, Bowen, Zhang, Shikai, Waterhouse, Geoffrey I.N., Liu, Xiaonan, Li, Houshen, Ai, Shiyun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.07.2024
• Subjects: Ag NPs; Density functional theory; Photodynamic sterilization; Porphyrin-based covalent organic frameworks; Ag NPs; Density functional theory; Porphyrin-based covalent organic frameworks; Photodynamic sterilization
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2024.152293

[Display omitted] •Ag NPs were loaded on a zinc porphyrin covalent organic framework (Ag@ZnPor-COF).•Ag@ZnPor-COF exhibits excellent ROS generation and photothermal capabilities.•Ag@ZnPor-COF demonstrated outstanding photodynamic antibacterial performance.•Near complete death of Staphylococcus aureus and Escherichia coli within 20 min. Porphyrin-based covalent organic frameworks (Por-COFs) show great promise in photodynamic sterilization and elimination of pathogenic bacteria. In this work, a two-dimensional Por-COF was constructed using 5,10,15,20-Tetrakis-(4-aminophenyl)-porphine-Zn(II) (Zn-TAPP) and Dihydroxyterephthalaldehyde (Dha), which was post-synthetically modified with silver nanoparticles (Ag NPs). Ag@ZnPor-COF delivered extraordinary photodynamic inactivation performance against Staphylococcus aureus and Escherichia coli under visible light (99.96 % and 99.75 %, respectively, within 20 min). The localized surface plasmon resonance of the Ag NPs enhanced the absorption of visible light whilst also aiding electron-hole separation, leading to efficient generation of reactive oxygen species (ROS), especially singlet oxygen (1O2). Further, the Ag NPs imparted Ag@ZnPor-COF with photothermal properties, thereby delivering even more effective control of pathogenic bacteria. Density functional theory (DFT) calculations validated the experimental findings, identifying Ag@ZnPor-COF as a potent antibacterial platform. Results encourage the wider use of Por-COFs and plasmonic nanomaterials in the development of antibacterial systems.