A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles

A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. (C) 2004 Elsevier Ltd. All rights reserved.

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 29; pp. 5581 - 5583
Main Authors Price, S, Bull, R, Cramp, S, Gardan, S, van den Heuvel, M, Neighbour, D, Osbourn, SE, de Esch, IJP, Buenemann, CL
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 12.07.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
guanidine
electrophilic sulfinylation
imidazole
trianion
sulfonamides
SEM
IMIDAZOLES
INHIBITORS
DERIVATIVES
LIGAND DESIGN
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Summary:A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. (C) 2004 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2004.05.143