The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases

The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M3-mAChR to the d...

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Published inInternational journal of molecular sciences Vol. 25; no. 14; p. 7560
Main Authors Liu, Xinxing, Yu, Yi, Zhang, Haiying, Zhang, Min, Liu, Yan
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 10.07.2024
Subjects
Adrenergic receptors
Apoptosis
Cardiac arrhythmia
cardiomyocyte
Cardiomyocytes
cardiovascular diseases
Circadian rhythm
endothelial cell
fibroblast
Heart attacks
Hypoxia
Ischemia
Kinases
Metabolism
muscarinic acetylcholine receptor M3
Nervous system
Pathophysiology
Proteins
Senescence
Small intestine
Smooth muscle
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Summary:The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M3-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M3-mAChR’s expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25147560