Synthesis and biological evaluation of chalcone incorporated thaizole-isoxazole derivatives as anticancer agents

• Published in: Chemical Data Collections Vol. 55; p. 101177
• Main Authors: Chaithanya, B., Chary, D. Prabhakara, Anna, Venkateshwara Rao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2025
• Subjects: (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop‑2-en-1-one; Chalcone and anticancer activity; Dasatinib; Thiazole; Dasatinib; Chalcone and anticancer activity; Thiazole; (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop‑2-en-1-one
• ISSN: 2405-8300; 2405-8300
• DOI: 10.1016/j.cdc.2024.101177

A new series of chalcone derivatives of thaizole-isoxazole derivatives (11a-j) and their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, all derivatives were investigated for their preliminary anticancer activity towards four human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) & A2780 (human ovarian cancer) by employing the MTT assay. Most of the tested compounds displayed remarkable anticancer activity compared to the positive control (etoposide). Among the various tested derivatives, five compounds 11a, 11 g, 11 h, 11i&11j exhibited more potent activity. Particularly, one compound 11j displayed the most promising activity (MCF-7 = 0.33 ± 0.085 µM; A549 = 0.12 ± 0.064 µM; Colo-205 = 0.77 ± 0.075 µM& A2780 = 0.93 ± 0.082 µM)..