Free-Radical Lipid Oxidation in the Rat Hypothalamus in Stress Following Cortisol Administration

Free-radical lipid oxidation processes were studied in the hypothalamus in rats after administration of cortisol. Three doses of cortisol (25 mg/kg/day) decreased the level of lipid oxidation end products – Schiff bases – by a mean factor of 1.4. Application of stress to control animals increased th...

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Published inNeuroscience and behavioral physiology Vol. 43; no. 4; pp. 502 - 504
Main Authors Flerov, M. A., Vyushina, A. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2013
Springer Nature B.V
Subjects
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Free radicals
Hormones
Hydrocarbons
Hypothalamus
Lipid peroxidation
Lipids
Neurobiology
Neurosciences
Oxidation
Physiology
Steroids
stress
cortisol
free-radical lipid oxidation
hypothalamus
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Summary:Free-radical lipid oxidation processes were studied in the hypothalamus in rats after administration of cortisol. Three doses of cortisol (25 mg/kg/day) decreased the level of lipid oxidation end products – Schiff bases – by a mean factor of 1.4. Application of stress to control animals increased the level of Schiff bases. In animals given cortisol, free-radical lipid oxidation process were significantly more marked than those in the stressed control group: along with an increase in end products (Schiff bases), there was a decrease in the intermediate products of free-radical oxidation. Thus, administration of cortisol can lead to longlasting changes in free-radical lipid oxidation in the hypothalamus of both control and stressed rats.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-013-9762-8