Microevolution in genomic short sequence repeats of Candida albicans in non‐neutropenic patients

The genome of the yeast Candida albicans harbours many genomic short sequence repeats (SSRs). These are stable upon transition of colonization to infection in immune‐compromised patients. We show here that in non‐neutropenic patients this transition may coincide with variation in several of the SSRs...

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Bibliographic Details
Published inYeast (Chichester, England) Vol. 24; no. 3; pp. 155 - 160
Main Authors Al‐Aidan, Al Waleed, Goessens, Wil, Lemmens‐den Toom, Nicole, Al‐Ahdal, Mohammed, van Belkum, Alex
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.03.2007
Subjects
Candida albicans
Candida albicans - genetics
Candida albicans - isolation & purification
Candidiasis - etiology
Candidiasis - genetics
Candidiasis - microbiology
DNA, Fungal - genetics
Emergency Service, Hospital
Evolution, Molecular
Genetic Variation
Humans
infection
Random Amplified Polymorphic DNA Technique
Repetitive Sequences, Nucleic Acid
SSR
trauma patients
VNTR
Wounds and Injuries - complications
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Summary:The genome of the yeast Candida albicans harbours many genomic short sequence repeats (SSRs). These are stable upon transition of colonization to infection in immune‐compromised patients. We show here that in non‐neutropenic patients this transition may coincide with variation in several of the SSRs. This may have implications for stage‐specific expression of C. albicans pathogenicity factors. Copyright © 2007 John Wiley & Sons, Ltd.
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SourceType-Scholarly Journals-1
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ISSN:0749-503X
1097-0061
DOI:10.1002/yea.1462