Effect of neonatal glucocorticoid treatment on bone mineralization of adult nontreated, dexamethasone-treated or vitamin D3-treated rats

1. Single neonatal dexamethasone (DEX) treatment significantly decreased the body weights of 5-month old male rats. There was no significant difference in females. 2. Bone mineral density (BMD) of neonatally DEX-treated male rats and bone mineral content (BMC) of double DEX-treated (neonatally and i...

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Bibliographic Details
Published inGeneral pharmacology Vol. 31; no. 5; pp. 789 - 791
Main Authors KARABELYOS, C, HORVATH, C, HOLLO, I, CSABA, G
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier 01.11.1998
Subjects
Aging - physiology
Animals
Animals, Newborn
Biological and medical sciences
Body Weight - drug effects
Bone Density - drug effects
Calcification, Physiologic - drug effects
Cholecalciferol - pharmacology
Dexamethasone - pharmacology
Drug toxicity and drugs side effects treatment
Female
Glucocorticoids - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Sex Factors
Space life sciences
Toxicity: osteoarticular system
Corticosteroid
Dexamethasone
Rat
Steroid hormone
Toxicity
Body weight
Rodentia
Antiinflammatory agent
Sex
Diseases of the osteoarticular system
Vitamin
Osteoarticular system
Vertebrata
Mammalia
Bone mass
Newborn animal
Subcutaneous administration
Bone
Somatic growth
Mechanism of action
Colecalciferol
Biological receptor
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Summary:1. Single neonatal dexamethasone (DEX) treatment significantly decreased the body weights of 5-month old male rats. There was no significant difference in females. 2. Bone mineral density (BMD) of neonatally DEX-treated male rats and bone mineral content (BMC) of double DEX-treated (neonatally and in adult age) males were reduced. 3. BMD and BMC calculated to body weight were highly significantly increased after neonatal or double DEX treatment in males. In females only BMC/body weight was elevated after double DEX treatment. 4. Adult vitamin D treatment completely compensated for the changes caused by single or double DEX treatment. 5. The results call attention to the imprinting effects of neonatal glucocorticoid treatment, which were manifested in changes of body weight and bone mineral mass. At the same time the gender-dependence of this phenomenon was demonstrated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(98)00093-7