Developmental antecedents of cardiovascular disease: a historical perspective

Knowledge of the fetal antecedents of cardiovascular disease has increased rapidly since the association between low birth weight and the disease was demonstrated 20 yr ago. It now is known that individuals who had low birth weight or who were thin or short at birth are at increased risk for both ca...

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Bibliographic Details
Published inJournal of the American Society of Nephrology Vol. 16; no. 9; pp. 2537 - 2544
Main Authors Barker, David J P, Bagby, Susan P
Format Journal Article
LanguageEnglish
Published United States 01.09.2005
Subjects
Adult
Animals
Birth Weight
Cardiovascular Diseases - embryology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - history
Cardiovascular System - embryology
Child
Child Development
Female
Fetal Development
History, 20th Century
History, 21st Century
Humans
Infant, Newborn
Kidney - embryology
Male
Models, Biological
Pregnancy
Risk Factors
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Summary:Knowledge of the fetal antecedents of cardiovascular disease has increased rapidly since the association between low birth weight and the disease was demonstrated 20 yr ago. It now is known that individuals who had low birth weight or who were thin or short at birth are at increased risk for both cardiovascular disease and type 2 diabetes. This has been shown in studies in different countries and cannot be explained by confounding variables. Through clinical and animal studies, the biologic processes that underlie the epidemiologic associations and how their effects are modified by postnatal growth and by living conditions in childhood and adult life are beginning to be understood. One such process is altered renal development, with reduced nephron numbers, which may initiate hypertension.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1046-6673
DOI:10.1681/ASN.2005020160