The regulation of epithelial cells volume in norm and pathology

The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of vo...

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Bibliographic Details
Published inBi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 16; no. 4; pp. 42 - 60
Main Authors Ponomarchuk, O. O., Маximov, G. V., Оrlov, S. N.
Format Journal Article
LanguageEnglish
Published Siberian State Medical University (Tomsk) 01.01.2017
Subjects
канцерогенез
миграция
пролиферация
регуляция объема
эпителиальные клетки
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Summary:The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of volume occurs due to the transport of osmolytes, which results in the restoration of the intracellular water volume and the normalization of cellular functions. In this review we focused on the physiological significance of regulatory volume decrease (RVD) and regulatory volume increase (RVI) in response to fluctuations of extra- and intracellular osmolarity in the context of epithelial cells.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2017-4-42-60