Oxidative radioiodination of meclofenoxate as a preclinical brain imaging agent
Meclofenoxate is a drug used to cause a broad improvement in brain function and mental performance. Meclofenoxate was successfully labeled with I via direct electrophilic substitution reaction at room temperature. Percent radiochemical yield was evaluated by paper electrophoresis and HPLC. The react...
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Published in | Radiochimica acta Vol. 104; no. 7; pp. 491 - 497 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
De Gruyter
28.07.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Meclofenoxate is a drug used to cause a broad improvement in brain function and mental performance. Meclofenoxate was successfully
labeled with
I via direct electrophilic substitution reaction at room temperature. Percent radiochemical yield was
evaluated by paper electrophoresis and HPLC. The reaction parameters affecting the preparation process were studied in
details.
I-meclofenoxate gave maximum percent radiochemical yield of about 95 ± 1.0% with specific activity
1.9 μCi/μg meclofenoxate and its stability was up to 4 h. Biodistribution studies showed that maximum
uptake of
I-meclofenoxate in the brain of mice was 4.27 ± 0.3% injected dose (ID)/g tissue organ at
15 min post-injection. This uptake of
I-meclofenoxate was found to be enough to image brain as it still
4.3% ID/g at 30 min post injection. |
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ISSN: | 0033-8230 2193-3405 |
DOI: | 10.1515/ract-2015-2557 |