Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense

The host type I interferon (IFN) response protects against infections. Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway and has not been well described. Here, we demonstrate that inhibits the IFN-β signaling pathway but doe...

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Bibliographic Details
Published inInfection and immunity Vol. 91; no. 11; p. e0036523
Main Authors Allen, Charles N S, Banks, Dallas A, Shuster, Michael, Vogel, Stefanie N, O'Connor, Tamara J, Briken, Volker
Format Journal Article
LanguageEnglish
Published United States 16.11.2023
Subjects
Humans
Interferon Type I
Interferon-gamma - metabolism
Legionella pneumophila - physiology
Legionnaires' Disease
Signal Transduction
Type IV Secretion Systems
Legionella pneumophila
nitric oxide
secretion systems
interferons
immune evasion
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Summary:The host type I interferon (IFN) response protects against infections. Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway and has not been well described. Here, we demonstrate that inhibits the IFN-β signaling pathway but does not inhibit IFN-γ-mediated cell signaling. The addition of IFN-β to -infected macrophages limited bacterial growth independently of NOS2 and reactive nitrogen species. The type IV secretion system of is required to inhibit IFN-β-mediated cell signaling. Finally, we show that the inhibition of the IFN-β signaling pathway occurs downstream of STAT1 and STAT2 phosphorylation. In conclusion, our findings describe a novel host cell signaling pathway inhibited by via its type IV secretion system.
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content type line 23
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.00365-23