Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients

The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the...

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Published inBi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 11; no. 4; pp. 32 - 38
Main Authors Ilyinskikh, Ye. N., Ilyinskikh, I. N., Semyonov, A. G., Fait, Ye. A., Shaitarova, M. V.
Format Journal Article
LanguageEnglish
Published Siberian State Medical University (Tomsk) 28.08.2012
Subjects
borrelia garinii
апоптоз
бромдезоксиуридин
иксодовый клещевой боррелиоз
интерлейкин-4
интерферон-g
клеточный цикл
проточная цитометрия
реакция бластной трансформации лейкоцитов
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Summary:The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2012-4-32-38