The Outcomes of Acute Coronary Syndrome in Patients Suffering From Schizophrenia: A Systematic Review

• Published in: Curēus (Palo Alto, CA) Vol. 13; no. 8; p. e16998
• Main Authors: Hannoodee, Hanan, Al Khalili, Mahmoud, Theik, Nyein Wint Yee, Raji, Oluwatimilehin E, Shenwai, Priya, Shah, Rutul, Kalluri, Sahithi Reddy, Bhutta, Tinaz H, Khan, Safeera
• Format: Journal Article
• Language: English
• Published: Palo Alto (CA) Cureus 08.08.2021
• Subjects: Cardiology; Internal Medicine; Psychiatry
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.16998

Acute coronary syndrome (ACS) is a principal cause of mortality and morbidity worldwide. Recent studies have suggested poorer outcomes in ACS patients who have a concurrent diagnosis of schizophrenia as compared with those without. However, the degree of interplay between schizophrenia and ACS remains poorly understood. For this reason, we conducted a systematic review on ACS outcomes in patients with schizophrenia by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We collected relevant data from PubMed, Cochrane Library, PubMed central, Jisc Library Hub Discover, and the National Library of Medicine (NLM) and performed a thorough quality appraisal. Fourteen shortlisted, relevant studies were meticulously reviewed. Mortality and major adverse cardiac events (MACE), bleeding, and stroke were more prevalent in patients with a schizophrenia diagnosis compared to those without. Additionally, schizophrenia patients received suboptimal care and follow-up when compared to patients without a psychiatric diagnosis. Clinicians need to be aware that patients with schizophrenia have worse outcomes following ACS which may relate to biological, health care, or patient-related factors.