Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella

• Published in: Journal of medical microbiology Vol. 73; no. 1
• Main Authors: Gestels, Zina, De Baetselier, Irith, Abdellati, Said, Manoharan-Basil, Sheeba Santhini, Kenyon, Chris
• Format: Journal Article
• Language: English
• Published: England 01.01.2024
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Depsipeptides - pharmacology; Drug Resistance, Bacterial; Gonorrhea - drug therapy; Gonorrhea - microbiology; Humans; Microbial Sensitivity Tests; Neisseria gonorrhoeae; lantibiotics; Neisseria gonorrhoeae; lipid II; ramoplanin; AMR; resistance

is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for infection. We tested the...