Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella
is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for infection. We tested the...
Saved in:
Published in | Journal of medical microbiology Vol. 73; no. 1 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.01.2024
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in
is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for
infection. We tested the effectiveness of ramoplanin
against 14 World Health Organization (WHO) reference strains of
and found that it was active against all 14 strains tested. Furthermore, in a
infection model of
WHO P, we demonstrated that ramoplanin was active
without any evidence of toxicity. This suggests that ramoplanin might be a new promising antibiotic treatment for gonorrhoea. |
---|---|
ISSN: | 1473-5644 |
DOI: | 10.1099/jmm.0.001785 |