Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella

is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for infection. We tested the...

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Bibliographic Details
Published inJournal of medical microbiology Vol. 73; no. 1
Main Authors Gestels, Zina, De Baetselier, Irith, Abdellati, Said, Manoharan-Basil, Sheeba Santhini, Kenyon, Chris
Format Journal Article
LanguageEnglish
Published England 01.01.2024
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Depsipeptides - pharmacology
Drug Resistance, Bacterial
Gonorrhea - drug therapy
Gonorrhea - microbiology
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae
lantibiotics
Neisseria gonorrhoeae
lipid II
ramoplanin
AMR
resistance
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Summary:is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for infection. We tested the effectiveness of ramoplanin against 14 World Health Organization (WHO) reference strains of and found that it was active against all 14 strains tested. Furthermore, in a infection model of WHO P, we demonstrated that ramoplanin was active without any evidence of toxicity. This suggests that ramoplanin might be a new promising antibiotic treatment for gonorrhoea.
ISSN:1473-5644
DOI:10.1099/jmm.0.001785