Transdermal delivery of some anti-emetics

One group of drugs that could be usefully delivered by the transdermal route are the anti-emetics. Representative examples of this class of drugs have been examined and their potential for transdermal delivery assessed. This has been achieved by an examination of their physicochemical properties fro...

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 123; no. 2; pp. 285 - 289
Main Authors Hadgraft, Jonathan, Pugh, W.John, Wolff, H.-michael
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 12.09.1995
Elsevier
Subjects
Anti-emetic
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Skin penetration
Transdermal delivery
Skin penetration
Transdermal delivery
Anti-emetic
Human
Evaluation
Absorption
Skin
Mathematical model
Pharmacokinetics
Route of administration
Antiemetic
Percutaneous route
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Summary:One group of drugs that could be usefully delivered by the transdermal route are the anti-emetics. Representative examples of this class of drugs have been examined and their potential for transdermal delivery assessed. This has been achieved by an examination of their physicochemical properties from which skin permeability can be predicted using a range of mathematical models. The results have been compared with data in the literature for the penetration of the drugs across rat skin. The predicted permeabilities have then been equated with the known clearance kinetics of the drugs to calculate probable plasma levels. In this way the feasibility of delivering these drugs transdermally can be assessed.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)00101-N