Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate

The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Prelimi...

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Bibliographic Details
Published inAustralian journal of chemistry Vol. 57; no. 3; pp. 227 - 232
Main Authors Loughlin, WA, Murphy, ME, Elson, KE, Henderson, LC
Format Journal Article
LanguageEnglish
Published CLAYTON Csiro Publishing 01.01.2004
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
BRINE SHRIMP
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Summary:The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Preliminary biological evaluation of the protected pyrrole oxazole 4 (LD50 1.13 mug mL(-1)) and the deprotected pyrrole oxazole 5 ( LD50 1.06 mug mL(-1)) for potential cytotoxicity was carried out.
ISSN:0004-9425
1445-0038
DOI:10.1071/CH03184