Species heterogeneity of hepatic α1-adrenoceptors: α1A-, α1B- and α1C-subtypes

• Published in: Biochemical and biophysical research communications Vol. 186; no. 2; pp. 760 - 767
• Main Authors: García-Sáinz, J.Adolfo, Romero-Avila, M.Teresa, Hernández, Rocio Alcántara, Macias-Silva, Marina, Olivares-Reyes, Alberto, González-Espinosa, Claudia
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 31.07.1992; Elsevier
• Subjects: Biological and medical sciences; Cell receptors; Cell structures and functions; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine); Molecular form; Rat; Liver; Rodentia; Rabbit; α1-Adrenergic receptor; Tissue specificity; Lagomorpha; Vertebrata; Mammalia; Guinea pig; Hepatocyte; Comparative study

α 1-Adrenergic activation stimulated phosphorylase and phosphoinositide turnover in hepatocytes from guinea pigs, rats and rabbits. Chlorethylclonidine inhibited these effects in rat and rabbit cells but not in guinea pig hepatocytes; low concentrations of 5-methyl urapidil blocked the α 1 actions i...