Acute pancreatitis related to hypercalcemia as initial manifestation of cancer: About 4 cases

Acute pancreatitis is a frequent gastrointestinal emergency seen in tertiary care hospitals. While gallstones and chronic alcohol consumption remain the most common causes, other etiologies can also be identified, notably hypercalcemia, which constitutes a rare yet deadly cause of acute pancreatitis...

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Bibliographic Details
Published inRadiology case reports Vol. 19; no. 2; pp. 753 - 759
Main Authors Amri, Fakhrddine, Bensalah, Youssef, Zazour, Abdelkrim, Aggari, Hanane El, Koulali, Hajar, Mqaddem, Ouiam El, Skiker, Imane, Ismaili, Zahi, Kharrasse, Ghizlane
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.02.2024
Subjects
Acute pancreatitis
Cancer
Fatal outcomes
Hypercalcemia
Hypercalcemia
Fatal outcomes
Acute pancreatitis
Cancer
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Summary:Acute pancreatitis is a frequent gastrointestinal emergency seen in tertiary care hospitals. While gallstones and chronic alcohol consumption remain the most common causes, other etiologies can also be identified, notably hypercalcemia, which constitutes a rare yet deadly cause of acute pancreatitis. Herein, we report 4 cases of AP related to hypercalcemia from malignancies: 2 cases of multiple myeloma, one case of rectal malignancy, and 1 case of medullary thyroid carcinoma associated with a parathyroid adenoma. Among these cases, one patient died, one developed exocrine and endocrine pancreatic insufficiency, and another progressed to end-stage chronic renal failure. Awareness of hypercalcemia of malignancy as an exceptional etiology of AP is crucial for timely diagnosis and appropriate management of these cases.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2023.11.017