Successful Treatment for Adult Precursor B-Cell Lymphoblastic Lymphoma Involving Central Nervous System Monitored by 18F-Fluorodeoxyglucose PET/CT Imaging

Precursor B-cell lymphoblastic lymphoma (PBLL) is a rare subtype of non-Hodgkin lymphoma originating from B-cell precursors. PBLL, as a solitary mass lesion affecting the central nervous system without leukemic disease at presentation, is quite uncommon. Here we report a rare PBLL case with Philadel...

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Published inFrontiers in oncology Vol. 10
Main Authors Shi, Xiang, Zhou, Weiyan, Xu, Mengqiao, Hua, Tao, Guan, Yihui
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 24.03.2020
Subjects
fluorodeoxyglucose (FDG)
imatinib
Oncology
PET/CT
Philadelphia chromosome
precursor B-cell lymphoblastic lymphoma
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Summary:Precursor B-cell lymphoblastic lymphoma (PBLL) is a rare subtype of non-Hodgkin lymphoma originating from B-cell precursors. PBLL, as a solitary mass lesion affecting the central nervous system without leukemic disease at presentation, is quite uncommon. Here we report a rare PBLL case with Philadelphia chromosome positivity. The 44-year-old male presented a solitary bulky mass primarily involving the left frontotemporal lobes and extended into the infratemporal fossa. Pretreatment PET/CT imaging showed avid 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake of the lesion. By aggressive chemotherapy and imatinib maintenance treatment, the patient achieved and remained in complete remission on another two consecutive PET/CT imaging follow-ups.
Bibliography:This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology
Reviewed by: Paul Thomas Winnard Jr, Johns Hopkins University, United States; Xudong Shen, Guizhou Medical University, China
These authors have contributed equally to this work
Edited by: Freimut Dankwart Juengling, Universität Bern, Switzerland
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.00334