The Number of Antibody-Producing Cells in the Parathymic Lymph Nodes and the Spleen Following Intraperitoneal Injection of Antigen

Summary Following i.p. injection of antigen in the rat, the parathymic lymph nodes are α major, if not the major, site of antibody-producing cells. Though they contain only one-tenth the number of nucleated cells, these nodes have essentially as many antibody-forming cells as does the entire spleen....

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Published inThe Journal of immunology (1950) Vol. 106; no. 5; pp. 1401 - 1403
Main Authors Hirsh, Dwight C, Steward, John P, Amkraut, Alfred A
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.05.1971
Subjects
Animals
Antibody Formation
Antibody-Producing Cells
Antigens - administration & dosage
Cell Count
Female
Hemocyanins
Hemolytic Plaque Technique
Injections, Intraperitoneal
Lymph Nodes - cytology
Lymph Nodes - immunology
Nitrophenols
Peritoneum - immunology
Rats
Spleen - cytology
Spleen - immunology
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Summary:Summary Following i.p. injection of antigen in the rat, the parathymic lymph nodes are α major, if not the major, site of antibody-producing cells. Though they contain only one-tenth the number of nucleated cells, these nodes have essentially as many antibody-forming cells as does the entire spleen. Technical limitations that occur when the spleen is employed for such studies are also minimized or absent when the PLN are used to determine the number of PFC by the modified Cunningham technique. Thus, the parathymic lymph nodes should receive increased attention in investigating the cellular kinetics of the immune response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.106.5.1401