A Randomised Interventional Study to Compare Autologous and Nonautologous Dural Substitutes Among Traumatic Brain Injury Patients
Abstract Objectives To determine and compare the effectiveness and safety of galea-pericranium autologous dural graft with nonautologous polypropylene (G-patch) dural substitute among traumatic brain injury (TBI) patients. Methods A prospective interventional randomized comparative study was condu...
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Published in | The Indian journal of neurotrauma Vol. 18; no. 1; pp. 26 - 31 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
Thieme Medical and Scientific Publishers Pvt. Ltd
01.06.2021
|
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
Objectives
To determine and compare the effectiveness and safety of galea-pericranium autologous dural graft with nonautologous polypropylene (G-patch) dural substitute among traumatic brain injury (TBI) patients.
Methods
A prospective interventional randomized comparative study was conducted at the Department of Neurosurgery from November 2013 to March 2015 after obtaining approval from the institutional ethicas committee. The study population included 50 cases of TBI which were divided into two groups of 25 each by the randomization technique and were treated either with autologous duraplasty (galea-pericranium) or nonautologous polypropylene (G-patch) dural substitute. The outcomes measured were time to duraplasty, blood loss, hospital stay, and the incidence of complications with the two techniques. The data were entered in a MS Excel spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. A
p
value of < 0.05 was considered statistically significant.
Results
The average time to harvest galea-pericranium was 5 minutes. Compared with the patients undergoing G-patch, the patients in group pericranium had comparable duraplasty time (minutes) (34.32 vs. 27.80,
p
= 0.44), significantly lower drain output (54.8 vs. 74.5,
p
= 0.017), comparable blood loss (322 vs. 308,
p
= 0.545), comparable blood transfusion (24% vs. 16%,
p
= 0.48), significantly lesser duration of hospital stay (8.6 vs. 10.44,
p
= 0.028), comparable wound infection (8% vs. 16%,
p
= 0.384), and comparable cerebrospinal fluid (CSF) leak (0% vs. 8%,
p
= 0.149).
Conclusion
The study showed that galea-pericranium and polypropylene dural patch are equally effective and safe dural substitutes in providing a dural seal to minimize the CSF leaks and infections among posttraumatic brain injury patients. |
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ISSN: | 0973-0508 2213-3739 |
DOI: | 10.1055/s-0040-1717216 |