Alicyclic beta-amino acids in Medicinal Chemistry

The structural element of alicyclic beta-amino acids shows some remarkable biological effects: For some 5- and 6-membered beta-amino acids a unique anti fungal activity has been observed, 7-membered beta-amino acid derivatives have been investigated for neurological disorders. The application of 5-,...

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Bibliographic Details
Published inAmino acids Vol. 29; no. 2; pp. 89 - 100
Main Authors Kuhl, A, Hahn, M G, Dumić, M, Mittendorf, J
Format Journal Article
LanguageEnglish
Published Austria 01.08.2005
Subjects
Amino acids
Amino Acids, Cyclic - chemistry
Antifungal Agents - chemistry
Biological effects
Central Nervous System Agents - chemistry
Cycloleucine - analogs & derivatives
Cycloleucine - chemical synthesis
Derivatives
Disorders
Dopamine Plasma Membrane Transport Proteins - metabolism
Fungi
Stereoisomerism
Structural members
Structure-Activity Relationship
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Summary:The structural element of alicyclic beta-amino acids shows some remarkable biological effects: For some 5- and 6-membered beta-amino acids a unique anti fungal activity has been observed, 7-membered beta-amino acid derivatives have been investigated for neurological disorders. The application of 5-, 6- and 7-membered alicyclic beta-amino acids in Medicinal Chemistry will be reported. [structure: see text]
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ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-005-0212-y