Bradykinin actions in the central nervous system: historical overview and psychiatric implications

• Published in: Acta neuropsychiatrica Vol. 36; no. 3; pp. 129 - 138
• Main Authors: Graeff, Frederico Guilherme, Joca, Sâmia, Zangrossi, Jr, Helio
• Format: Journal Article
• Language: English
• Published: England 01.06.2024
• Subjects: Animals; Bradykinin - metabolism; Central Nervous System - drug effects; Central Nervous System - metabolism; Depressive Disorder - drug therapy; Depressive Disorder - metabolism; Humans; Mental Disorders - drug therapy; Mental Disorders - metabolism; Panic Disorder - metabolism; intracerebral injection; panic models; dorsal periaqueductal grey; Neuroactive peptide; psychiatric disorders
• ISSN: 0924-2708; 1601-5215
• DOI: 10.1017/neu.2023.57

Bradykinin (BK), a well-studied mediator of physiological and pathological processes in the peripheral system, has garnered less attention regarding its function in the central nervous system, particularly in behavioural regulation. This review delves into the historical progression of research focused on the behavioural effects of BK and other drugs that act via similar mechanisms to provide new insights into the pathophysiology and pharmacotherapy of psychiatric disorders. Evidence from experiments with animal models indicates that BK modulates defensive reactions associated with panic symptoms and the response to acute stressors. The mechanisms are not entirely understood but point to complex interactions with other neurotransmitter systems, such as opioids, and intracellular signalling cascades. By addressing the existing research gaps in this field, we present new proposals for future research endeavours to foster a new era of investigation regarding BK's role in emotional regulation. Implications for psychiatry, chiefly for panic and depressive disorders are also discussed.