The role of glucagon-like peptide 1 in glucose homeostasis and in other aspects of human physiology

This paper reviews the structure, function, and pathophysiology of glucagon-like peptide 1 (GLP-1). It describes the physiology and pathophysiology of the incretin axis, of which GLP-1 is a component, as well as the biosynthesis, secretion, activity, and degradation of this intestinal hormone. Effec...

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Published inPolskie archiwum medycyny wewne̦trznej Vol. 119; no. 11; pp. 743 - 751
Main Authors Franek, Edward, Gajos, Grzegorz, Gumprecht, Janusz, Kretowski, Adam, Zahorska-Markiewicz, Barbara, Małecki, Maciej T
Format Journal Article
LanguageEnglish
Published Poland 01.11.2009
Subjects
Animals
Cardiovascular System - metabolism
Central Nervous System - physiology
Gastric Emptying - physiology
Glucagon-Like Peptide 1 - metabolism
Homeostasis - physiology
Humans
Pancreas - physiology
Receptors, Glucagon - metabolism
Receptors, Glucagon - physiology
Water-Electrolyte Balance - physiology
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Summary:This paper reviews the structure, function, and pathophysiology of glucagon-like peptide 1 (GLP-1). It describes the physiology and pathophysiology of the incretin axis, of which GLP-1 is a component, as well as the biosynthesis, secretion, activity, and degradation of this intestinal hormone. Effects of GLP-1 on the endocrine function of the pancreas, cardiovascular system, central nervous system, and on water-electrolyte balance have been also presented.
ISSN:1897-9483
1897-9483
DOI:10.20452/pamw.829