Agave mapisaga aqueous extract shows in vitro and in vivo activity on murine prostate cancer cells

Plants are a source of multiple antineoplastic treatments. However, the effect of many species used in traditional medicine has yet to be demonstrated. In this work, the taxonomic identification of Agave mapisagawas made and a high-performance liquid chromatography-mass spectrometry (HPLC-MS) study...

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Published inBoletín latinoamericano y del Caribe de plantas medicinales y aromáticas Vol. 23; no. 1; pp. 37 - 47
Main Authors Hernandez-Peralta, Pablo, Garcia-Espejo, David A, Gracia-Mora, Maria I, Velasco-Velasquez, Marco A, Cobos-Marin, Laura
Format Journal Article
LanguageEnglish
Published 01.01.2023
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Summary:Plants are a source of multiple antineoplastic treatments. However, the effect of many species used in traditional medicine has yet to be demonstrated. In this work, the taxonomic identification of Agave mapisagawas made and a high-performance liquid chromatography-mass spectrometry (HPLC-MS) study suggested the presence of the aglycone hecogenin, which is part of compounds such as agavoside C and cantalasaponin 4. The antineoplastic activity of an aqueous extract was tested in vitroand in vivoon PEC-Src epithelial murine prostate cancer cells. In vitrostudy revelead a significant chemosensivity at 0.125mg/100μL(p=0.0001). Also, in in vivo, using an isotransplantation model with 1x106cells subcutaneously, it was observed that the group treated with 50 mg/kg presented a lower tumor implantation compared with the control without treatment (p=0.04).
ISSN:0717-7917
0717-7917
DOI:10.37360/blacpma.23.22.1.3