A switching lung mechanics model for detection of expiratory flow limitation

Expiratory flow limitation (EFL) is an often unrecognized clinical condition with a multitude of negative implications. A mathematical EFL model is proposed to detect flow limitations automatically. The EFL model is a switching one-compartment lung mechanics model with a volume-dependent airway resi...

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Bibliographic Details
Published inAutomatisierungstechnik : AT Vol. 72; no. 5; pp. 417 - 428
Main Authors Hennigs, Carlotta, Bilda, Franziska, Graßhoff, Jan, Walterspacher, Stephan, Rostalski, Philipp
Format Journal Article
LanguageEnglish
Published De Gruyter 27.05.2024
Subjects
Berechnungsmodell
computational model
EFL
flow limitation
Flusslimitierung
lung mechanics
Lungenmechanik
mechanical ventilation
mechanische Beatmung
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Summary:Expiratory flow limitation (EFL) is an often unrecognized clinical condition with a multitude of negative implications. A mathematical EFL model is proposed to detect flow limitations automatically. The EFL model is a switching one-compartment lung mechanics model with a volume-dependent airway resistance to simulate the dynamic behavior during expiration. The EFL detection is based on a breath-by-breath model parameter identification and validated on clinical data of mechanically ventilated patients. In the group 93.9 % ± 5 % and in the group 10.2 % ± 13.7 % of the breaths are detected as EFL. Based on the high detection rate of EFL, these results support the usefulness of the EFL detection. It is a first step toward an automated detection of EFL in clinical applications and may help to reduce underdiagnosis of EFL.
ISSN:0178-2312
2196-677X
DOI:10.1515/auto-2023-0206