Detection of paraprotein in plasma cell tumors

Paraprotein is a laboratory biomarker of plasma cell tumors and other lymphoproliferative diseases. Its determination is necessary for diagnosing, monitoring and assessment of therapy effectiveness. The lecture presents the main methods of qualitative and quantative analysis of monoclonal proteins:...

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Published inTerapevtic̆eskii arhiv Vol. 94; no. 1; pp. 135 - 144
Main Authors Rekhtina, Irina G., Mendeleeva, Larisa P., Soboleva, Natalia P., Dubina, Irina A., Pervakova, Margarita Iu, Lapin, Sergey V.
Format Journal Article
LanguageEnglish
Published "Consilium Medicum" Publishing house 15.01.2022
Subjects
multiple myeloma
paraprotein
plasma cell disease
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Summary:Paraprotein is a laboratory biomarker of plasma cell tumors and other lymphoproliferative diseases. Its determination is necessary for diagnosing, monitoring and assessment of therapy effectiveness. The lecture presents the main methods of qualitative and quantative analysis of monoclonal proteins: gel electrophoresis, capillary electrophoresis, immunofixation and nephelometry features, possibilities and limitations are reviewed. The main sources of errors and artifacts during these studies are considered. Also the difficulties in the diagnosis and interpretation of the results of serum and urine tests are highlighted.
ISSN:0040-3660
2309-5342
DOI:10.26442/10.26442/00403660.2022.01.201326