Diversity and antigenic potentials of Mycoplasmopsis bovis secreted and outer membrane proteins within a core genome of strains isolated from North American bison and cattle
is a worldwide economically important pathogen of cattle that can cause or indirectly contribute to bovine respiratory disease. is also a primary etiological agent of respiratory disease in bison with high mortality rates. A major challenge in the development of an efficacious vaccine is the design...
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Published in | Genome Vol. 67; no. 6; p. 204 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Canada
01.06.2024
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Subjects | |
Online Access | Get more information |
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Summary: | is a worldwide economically important pathogen of cattle that can cause or indirectly contribute to bovine respiratory disease.
is also a primary etiological agent of respiratory disease in bison with high mortality rates. A major challenge in the development of an efficacious
vaccine is the design of antigens that contain both MHC-1 and MHC-2 T-cell epitopes, and that account for population level diversity within the species. Publicly available genomes and sequence read archive libraries of 381
strains isolated from cattle (
= 202) and bison (
= 179) in North America were used to identify a core genome of 575 genes, including 38 that encode either known or predicted secreted or outer membrane proteins. The antigenic potentials of the proteins were characterized by the presence and strength of their T-cell epitopes, and their protein variant diversity at the population-level. The proteins had surprisingly low diversity and varying predictive levels of T-cell antigenicity. These results provide a reference for the selection or design of antigens for vaccine testing against strains infecting North American cattle and bison. |
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ISSN: | 1480-3321 |
DOI: | 10.1139/gen-2023-0084 |