Mechanisms of di (2‐Ethylhexyl) Phthalate‐Induced Lipid Metabolism Disorders: A Review

• Published in: Journal of applied toxicology
• Main Authors: Fang, Xiaoqi, Wang, Tianrun, Lou, Shihao, Qiao, Ying, Zhang, Bo, Zhou, Liting
• Format: Journal Article
• Language: English
• Published: England 28.07.2025
• Subjects: multiple omics; pathophysiological changes; DEHP; lipid metabolism disorders
• ISSN: 0260-437X; 1099-1263; 1099-1263
• DOI: 10.1002/jat.4867

Di(2‐ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP‐induced lipid metabolism disorder. This review discusses the cellular pathophysiological changes leading to lipid metabolism disorders, including inflammation, apoptosis, autophagy, and oxidative stress. We also summarize the key molecules and signaling pathways involved in the lipid metabolism disorder induced by DEHP. Additionally, multiple omics such as metabolomics, transcriptomics, and epigenetics are discussed in this review. Furthermore, this article provides some directions for future research about the mechanisms of lipid metabolism disorders caused by DEHP, aiming to offer more detailed and reliable theoretical evidence for the prevention and treatment of lipid metabolism disorders. Di(2‐ethylhexyl) phthalate (DEHP), a common plasticizer, disrupts lipid metabolism via cellular pathophysiological changes, including inflammation, oxidative stress, apoptosis, and autophagy. This review highlights key molecular mechanisms and signaling pathways involved in DEHP‐induced metabolic dysregulation, integrating evidence from metabolomic, transcriptomic, and epigenetic studies. By summarizing current findings and identifying research gaps, this work aims to advance understanding of DEHP's metabolic impacts, providing insights for future preventive and therapeutic strategies against lipid metabolism disorders.