Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donor

The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3- tert -butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO 2 ) and two antitumor cytostatics, cisplatin and doxorubicin, was studied in vivo using a model of P-388 murine leukemia of...

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Published inRussian chemical bulletin Vol. 71; no. 3; pp. 517 - 523
Main Authors Bogatyrenko, T. N., Kandalintseva, N. V., Sashenkova, T. E., Allayarova, U. Yu, Mishchenko, D. V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2022
Springer Nature B.V
Subjects
Anticancer properties
Antioxidants
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Doxorubicin
Full Articles
Inorganic Chemistry
Leukemia
Nitric oxide
Organic Chemistry
Sodium nitrite
Sulfur
Survival
nitric oxide
doxorubicin
cisplatin
sulfur-containing phenolic antioxidant
metronomic therapy
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Summary:The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3- tert -butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO 2 ) and two antitumor cytostatics, cisplatin and doxorubicin, was studied in vivo using a model of P-388 murine leukemia of BDF 1 mice. It has been shown that the type of cytostatics used determines the efficiency of chemotherapy. Depending on this, the antioxidant TS-13 can both enhance and reduce the antitumor effect. The use of TS-13 and a nitric oxide donor with different cytostatics and different modes of drug administration modulates their activity in different ways, namely, from increasing survival to inhibition of survival.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3442-1