Species differences in the cardiovascular responses to histamine H3 receptor activation

• Published in: European journal of pharmacology Vol. 259; no. 2; pp. 211 - 214
• Main Authors: MCLEOD, R. L, GERTNER, S. B, HEY, J. A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 01.07.1994
• Subjects: Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Cardiology. Vascular system; Cimetidine - pharmacology; Experimental diseases; Guinea Pigs; Heart Rate - drug effects; Hemodynamics - drug effects; Histamine Agonists - pharmacology; Histamine Antagonists; Male; Medical sciences; Methylhistamines - pharmacology; Piperidines - pharmacology; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Histamine H3 - metabolism; Species Specificity; Heart; Hypertension; Heart rate; H3 receptor; Animal; Interspecific comparison; Cardiovascular disease; Arterial pressure; Activation; Hemodynamics
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(94)90512-6

Potential species differences in cardiovascular responses to histamine H3 receptor activation were studied in the conscious guinea pig, rabbit, normotensive rat and the spontaneously hypertensive rat. R-alpha-Methylhistamine (100 micrograms/kg i.v.) decreased blood pressure in both the guinea pig and the rabbit. In the guinea pig, R-alpha-methylhistamine decreased heart rate, whereas in the rabbit it produced a tachycardia. In the normotensive rat and spontaneously hypertensive rat, R-alpha-methylhistamine (100 micrograms/kg i.v.) had no effect on blood pressure and heart rate. The cardiovascular action of R-alpha-methylhistamine in the guinea pig and rabbit was blocked by pretreatment with thioperamide (1.0 mg/kg i.v.) but not by chlorpheniramine (0.3 mg/kg i.v.) or cimetidine (3.0 mg/kg i.v.), respectively. These results indicate species differences in cardiovascular responses to histamine H3 receptor activation.